Backed By Science
Proceive is a range of scientifically formulated supplements tailored for each stage of conception, pregnancy, and breastfeeding. Based on research by fertility and medical experts using a wide range of clinical studies, Proceive provide the most functional, comprehensive and evidence based nutritional supplements for men and women at each life stage.
Below is a selection of the many scientific studies referenced in the development of Proceive.
Scientific Studies
Antioxodants
The Role of Oxidative Stress and Antioxidants in Male Fertility
Renata Walczak–Jedrzejowska, Jan Karol Wolski, and Jolanta Slowikowska– Hilcze. Cent. European J Urol. 2013; 66(1): 60–67. Published online 2013 Apr 26.
Impact of Oxidative Stress on Female Fertility
Elizabeth H. Ruder, Terryl J. Hartman and Marlene B. Goldman Curr Opin Obstet Gynecol. 2009 Jun; 21(3): 219–222.
Amino Acids
Effect of L-carnitine and L-Acetyl-Carnitine in Nutrition Treatment for Male Infertility: A Systematic Review
Zhou X, Liu F, Zhai S, Asia Pac J Clin Nutr. 2007; 1 Suppl 1:383-90.
B Vitamins
Use of Multivitamins, Intake of B Vitamins and Risk of Ovulatory Infertility
Jorge E. Chavarro, MD, ScD, Janet W. Rich-Edwards, ScD, MPH, Bernard A. Rosner, PhD, and Walter C. Willett, MD, DrPH. Fertil Steril. 2008 Mar; 89(3): 668–676.
MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta- AnalysisInvolving 26 Studies
Mancheng Gong, Wenjing Dong, Tingyu He, Zhirong Shi, Guiying Huang, Rui Ren, Sichong Huang, Shaopeng Qiu, and Runqiang Yuan. PLoS One. 2015; 10(3): e0121147. Published online 2015 Mar 20.
Calcium
TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis
Prashant B. Shambharkar, Mark Bittinger, Brian Latario,ZhaoHui Xiong, Somnath Bandyopadhyay, Vanessa Davis, Victor Lin, Yi Yang Reginald Valdez, and Mark A. Labow. PLoS One, 2015; 10(5): e0127480.
Calcium and Vitamin D: Important at Every Age. NIH (2018). NIH Osteoporosis and Related Bone Diseases National Resource Center
[online] Nih.gov. Available at: https://www.bones.nih.gov/healthinfo/bone/bone-health/nutrition/calcium-and-vitamin-d-important-every-age.
Effects of Selenium, Calcium and Calcium Ionophore on Human Oocytes in Vitro Maturation in a Chemically Defined Medium
Mehri Makki, M.Sc., Elham Saboori, M.Sc., Mohammad Ali Sabbaghi, M.Sc., Raheleh Aram, M.Sc., Mohammad Hasan Fallahian, M.Sc., Fatemeh Peyghambari, Ph.D., Hessam Roustaei, M.D., and Abbas Ahmadi, Ph.D. Iran J Reprod Med. 2012 Jul; 10(4): 343–348.
Coenzyme Q10
Can Coenzyme Q10 Supplementation Protect the Ovarian Reserve Against Oxidative Damage?
Özcan P, Fıçıcıoğlu C, Kizilkale O, Yesiladali M, Tok OE, Ozkan F, Esrefoglu M. J Assist Reprod Genet. 2016 Sep; 33(9):1223-30.
Coenzyme Q10 Restores Oocyte Mitochondrial Function and Fertility During Reproductive Aging
Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A. Aging Cell. 2015 Oct;14(5):887-95.
Coenzyme Q10: The Essential Nutrient
Saini R. J Pharm Bioallied Sci. 2011 Jul;3(3):466-7. doi: 10.4103/0975-7406.84471. PMID: 21966175; PMCID: PMC3178961.
Copper
Micronutrient Status in Female University Students: Iron, Zinc, Copper, Selenium, Vitamin B12 and Folate
Flavia Fayet-Moore, Peter Petocz, and Samir Samman Nutrients. 2014 Nov; 6(11): 5103–5116.
Genome-Wide Association Study Identifies Loci Affecting Blood Copper, Selenium and Zinc
David M. Evans, Gu Zhu, Veronica Dy, Andrew C. Heath, Pamela A. F. Madden, John P. Kemp, George McMahon, Beate St Pourcain, Nicholas J. Timpson, Jean Golding, Debbie A. Lawlor, Colin Steer, Grant W. Montgomery, Nicholas G. Martin, George Davey Smith, and John B. Whitfield Hum Mol Genet. 2013 Oct 1; 22(19): 3998–4006.
Vitamin D
The Role of Vitamin D in Uterine Fibroid Biology
Soumia Brakta, MD, Justin S. Diamond, BS, Ayman Al-Hendy, MD PhD, Michael P. Diamond, MD, and Sunil K. Halder, PhD. Fertil Steril. 2015 Sep; 104(3): 698– 706. Published online 2015 Jun 13.
Immune Aspects of Female Infertility
Andrea Brazdova, Ph.D, Helene Senechal, Ph.D, Gabriel Peltre,Ph.D, and Pascal Poncet, Ph.D. Int J Fertil Steril. 2016 Apr-Jun; 10(1): 1–10. Relevance of vitamin D in reproduction, Janelle Luk, Saioa Torrealday, Genevieve Neal Perry and Lubna Pal. Hum Reprod. 2012 Oct; 27(10): 3015–3027. Published online 2012 Jul 23.
Vitamin E
Selenium–Vitamin E Supplementation in Infertile Men: Effects on Semen Parameters and Pregnancy Rate
Moslemi MK, Tavanbakhsh S Int J Gen Med. 2011 Jan 23;4:99-104.
The Vitamin E–Binding Protein Afamin is Altered Significantly in the Peritoneal Fluid of Women with Endometriosis
Beata E. Seeber, M.D., M.S.C.E., Theresa Czech, M.D.,Hannes Buchner, M.S.,Kurt T. Barnhart, M.D., M.S.C.E.,Christoph Seger, Ph.D.,Guenter, Daxenbichler, Ph.D.,Ludwig Wildt, M.D. and Hans Dieplinger, Ph.D. Fertil Steril. 2010 Dec; 94(7): 2923–2926.
Folic Acid / Folate / L-Methylfolate
Scientific Opinion on the Substantiation of a Health Claim Related to Increasing Maternal Fo-late Status by Supplemental Folate Intake and Reduced Risk of Neural Tube Defects Pursuant to Article 14 of Regulation (EC) No 1924/2006, EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
accessible at: https://doi.org/10.2903/j.efsa.2013.3328
Calcium L‐methylfolate as a Source of Folate added for Nutritional Purposes to Infant and Fol-low on Formula, Baby Food and Processed Cereal‐based Food
EFSA Journal 2020;18(1):5947, accessible at: https://doi.org/10.2903/j.efsa.2020.5947
Folic Acid Supplementation and Pregnancy: More Than Just Neural Tube Defect Prevention.
Greenberg JA, Bell SJ, Guan Y, Yu YH. Rev Obstet Gynecol. 2011 Summer;4(2):52-9. PMID: 22102928; PMCID: PMC3218540.
Iodine
Thyroid Homeostasis in Mother–Child Pairs in Relation to Maternal Iodine Status: the MISA study
V Berg,T H Nøst, G Skeie, Y Thomassen, B Berlinger, A S Veyhe, R Jorde, J Ø Odland, and S Hansen Eur J Clin Nutr. 2017 Aug; 71(8): 1002–1007.
The WOMED Model of Benign Thyroid Disease: Acquired Magnesium Deficiency Due to Physi-cal and Psychological Stressors Relates to Dysfunction of Oxidative Phosphorylation
Roy Moncayo and Helga Moncayo. BBA Clin. 2015 Jun; 3: 44–64.
Iron
Adequately Diversified Dietary Intake and Iron and Folic Acid Supplementation during Pregnan-cy Is Associated with Reduced Occurrence of Symptoms Suggestive of Pre-Eclampsia or Ec-lampsia in Indian Women
Sutapa Agrawal, Jasmine Fledderjohann, Sukumar Vellakkal, and Da-vid Stuckler. PLoS One. 2015; 10(3): e0119120.
Use of Multivitamins, Intake of B Vitamins and Risk of Ovulatory Infertility
Jorge E. Chavarro, MD, ScD, Janet W. Rich-Edwards, ScD, MPH, Bernard A. Rosner, PhD, and Walter C. Willett, MD, Dr PH. Fertil Steril. 2008 Mar; 89(3): 668–676.
L-Carnitine
The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation
Virmani MA, Cirulli M. Int J Mol Sci. 2022 Feb 28;23(5):2717. doi: 10.3390/ijms23052717. PMID: 35269860; PMCID: PMC8910660.
Magnesium
The Role of Magnesium and Thyroid Function in Early Pregnancy after In-Vitro Fertilization (IVF): New aspects in endocrine physiology
Sibilla Stuefer, Helga Moncayo, and Roy Moncayo. BBA Clin. 2015 Jun; 3: 196– 204.
Association Between Seminal Plasma Copper and Magnesium Levels with Oxidative Stress in Iraqi Infertile Men
Omar F. Abdul-Rasheed Oman Med J. 2010 Jul; 25(3): 168–17.
Omega 3
Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids
Deepika Nehra, Hau D. Le, Erica M. Fallon, Sarah J. Carlson, Dori Woods, Yvonne A. White, Amy H. Pan, Lankai Guo, Scott J. Rodig, Jonathan L. Tilly, Bo R. Rueda, and Mark Puder. Aging Cell. 2012 Dec; 11(6): 1046–1054.
The effect of omega-3 supplementation on androgen profile and menstrual status in women with polycystic ovary syndrome: A randomized clinical trial
Azadeh Nadjarzadeh, Ph.D. Razieh Dehghani Firouzabadi, M.D., Niloofar Vaziri, M.Sc., Hoorieh Daneshbodi, M.Sc., Mohammad Hassan Lotfi, M.D.,Ph.D., and Hassan Mozaffari-Khosravi, Ph.D. Iran J Reprod Med. 2013 Aug; 11(8): 665–672.
Nutrition and Reproductive Health: Sperm versus Erythrocyte Lipidomic Profile and O-3 Intake
Gabriela Ruth Mendeluk, Mariano Isaac Cohen, Carla Ferreri, and Chryssostomos Chatgili-aloglu. J Nutr Metab. 2015; 2015: 670526.
Selenium
Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids
Deepika Nehra, Hau D. Le, Erica M. Fallon, Sarah J. Carlson, Dori Woods, Yvonne A. White, Amy H. Pan, Lankai Guo, Scott J. Rodig, Jonathan L. Tilly, Bo R. Rueda, and Mark Puder. Aging Cell. 2012 Dec; 11(6): 1046–1054.
Role of oxidative stress in female reproduction
Agarwal A Gupta S, Sharma RK. Reprod Biol Endocrinol. 2005 Jul 14;3:28.
Zinc
Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome
Trine Maxel, Pernille Fog Svendsen, Kamille Smidt, Jesper Krogh Lauridsen, Birgitte Brock, Steen Bønlykke Pedersen, Jørgen Rungby, and Agnete Larsen. Front Endocrinol (Lausanne). 2017; 8: 38
Acute dietary zinc deficiency before conception compromises oocyte epigenetic programming and disrupts embryonic development
X Tian and FJ Diaz. Dev Biol. 2013 Apr 1; 376(1): 51–61.
Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation
Riccardo Talevi, Vincenza Barbato, Ilaria Fiorentino, Sabrina Braun, Salvatore Longobardi, and Roberto Gualtieri. Reprod Biol En-docrinol. 2013; 11: 81.





